1
You're right, Matt. Ryan is the only one with 9+ K/9 and under 100 ISO-against for his career. He faced over 22,000 batters.
Kershaw is at 100 on the nose at this moment.
There are only nine guys with 9+ K/9 with a minimum of 1000 IP:
1. Randy Johnson 10.6 K/9 --- .132 ISO-against
2. Kerry Wood 10.3 K/9 --- .143 ISO-against
3. Pedro Martinez 10.0 K/9 --- .123 ISO-against
4. Tim Lincecum 9.7 K/9 --- .121 ISO-against
5. Nolan Ryan 9.5 K/9 --- .094 ISO-against
6. Trevor Hoffman 9.4 K/9 --- .131 ISO-against
7. Sandy Koufax 9.3 K/9 --- .114 ISO-against
8. Oliver Perez 9.2 K/9 --- .172 ISO-against
9. Clayton Kershaw 9.2 K/9 --- .100 ISO-against